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This methylation profile is by now acquired in the MBL stage3 and remains relatively secure over time. However, some CLL have intratumor variability in particular regions, which may change the expression of a number of genes and aid tumor evolution.seventy one Of Notice, this variability is larger in U-CLL than in M-CLL and is also linked to rising amount of subclones.7,seventy one
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mutations and complex kar yotype. It follows a linear evolution from the CLL clone in the recurrent acquisition of CDKN2A